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The PSA Formula

• Beta Sitosterol - This plant sterol inhibits 5-alpha reductase, the enzyme that converts testosterone to harmful dihydrotestosterone (DHT) and aromatase, an enzyme that catalyzes the conversion of testosterone to unwanted harmful estrogens, estradiol and estrone, elevated levels of which are an underlying cause of enlarged prostate. Beta sitosterol has been reported to reduce BPH-related symptoms, including cancer growths in the prostate gland. Beta sitosterol has been demonstrated to improve urine flow velocity in men with enlarged prostate, while also providing anti-inflammatory effects in prostate tissue, which helps reduce BPH symptoms, enlarged prostate, and potential cancer cell mutations.
• Saw Palmetto Extract (Seronoa repens) - The extract from this plant (a creeping palm with a trunk that lies on or just below the ground surface) is arguably the most frequently used herbal treatment for prostate problems, with several research studies demonstrating that a 45-90 day treatment for enlarged prostate leads to a significant clinical improvement. Saw Palmetto (320 mg per day) inhibits 5-Alpha Reductase, the enzyme that catalyzes the conversion of testosterone to dihydrotestosterone (DHT), reducing DHT by 66% in the periurethral region of the prostate gland, and by 50% in the prostate gland. Saw Palmetto also reduces epidermal growth factor (EGF). Men using Saw Palmetto for the treatment of enlarged prostate generally begin to notice relief from their symptoms within the first 30 days of use.
• Stinging Nettle (Urtica dioica Root Extract 4:1) - The active ingredient in this herb-like shrub inhibits the ability of epidermal growth factor (EGF) to bind to its receptors in the prostate and to subsequently stimulate the growth of prostate tissue (a key underlying factor in the progression of enlarged prostate). Other uses for Stinging nettle include treatment for urinary tract infections, kidney stones, and hay fever.
• Epilobium (small flower willow) - Epilobium contains two polyphenols (Oenothein A, Oenothein B), which inhibit the 5-alpha reductase enzyme conversion of testosterone to DHT. Epilobium also inhibits aromatase from converting testosterone to estrogens, which happens in older males as they age, helping to reduced harmful DHT, estradiol, and estrone levels, which are known to contribute to prostate-related disorders. Epilobium also inhibits two types of prostaglandin 2's (especially E-2), which have undesirable pro-inflammatory effects.
• Lycopene - This member of the carotenoid family (it produces the red/reddish color in tomatoes, watermelon, pink grapefruit, guava & papaya) is a powerful antioxidant that protects the Deoxyribonucleic Acid (DNA) content of lymphocytes (cells found in the blood, lymph, and lymphoid tissues) from oxidative damage. It interferes with the ability of Insulin-like Growth Factor-1 (IGF) to stimulate the proliferation of various types of cancers in the breast, endometrial and prostate tissue. Research reports that endurance cyclists suffer from prostate disorders, erectile dysfunction, reduced sperm motility, and reduced sperm counts. Using 50 volunteers with low active sperm counts, researchers gave subjects 8 mg/d of lycopene during this one-year study; 35 patients experienced an improvement in sperm count, and 30 had improved functional sperm concentrations. There was a 36% pregnancy rate among the participants' partners by the end of the study.
• Alanine, Glutamic Acid, Glycine - These amino acids, when taken for 14 days or more, minimized the symptoms of enlarged prostate. In order to positively affect/influence several hormonal pathways involving prostate health, these particular amino acids should be consumed 60+ minutes before other amino acids (or protein-containing foods) are consumed.